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About Avectas

Avectas is a cell engineering technology business, enabling the manufacture of cell therapies. Avectas’ technology, Solupore®, delivers advanced molecules such as mRNA, proteins and gene editing tools to a range of primary cell types including T cells for immuno-oncology and gene editing applications. Solupore® utilizes a membrane disruptive approach to rapidly deliver advanced molecules to cells. It is a simple, rapid and gentle process that yields superior engineered cells. Solupore® results in improved cell processing times and cell health relative to viral vectors and electroporation, leading to a more cost-effective manufacturing process. Avectas is currently partnering with immuno-oncology and gene editing businesses to deliver their proprietary molecules. Avectas is also seeking therapeutic molecules to in-license as the core of a therapeutic program.

Our vision is to become the gold standard in vector-free intracellular delivery.


Technology Overview

Intracellular delivery is achieved by reversible permeabilization using a fluid handling process.

Step 1

A population of suspension or adherent cells can be modified within 4 minutes. Media is removed through the filter membrane.

A population of suspension or adherent cells can be modified within 4 minutes. Media is removed through the filter membrane.

Step 2

The cargo is mixed with the proprietary delivery solution and applied to the cells with precise control of volume and application time.

The cargo is mixed with the proprietary delivery solution and applied to the cells with precise control of volume and application time.

Step 3

The delivery solution gently permeabilizes the cell membrane and the cargo rapidly diffuse into the cell.

The delivery solution gently permeabilizes the cell membrane and the cargo rapidly diffuse into the cell.

Step 4

The permeabilization solution is replaced with a recovery solution which results in high cell viability and functionality levels.

The permeabilization solution is replaced with a recovery solution which results in high cell viability and functionality levels.